Bacterial Strategies to Maintain Zinc Metallostasis at the Host-Pathogen Interface

DAIANA CAPDEVILA; JIEFEI WANG; DAVID GIEDROC

JOURNAL OF BIOLOGICAL CHEMISTRY

AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

Lugar: Bethesda, Maryland; Año: 2016

0021-9258

Amongthe biologically required first row, late d-block metalsfrom MnII to ZnII, the catalytic and structural reach of ZnII ensures that this essential micronutrient touches nearly every majormetabolic process orpathwayin the cell.Znis also toxic in excess, primarily because it is a highly competitive divalent metal and will displace more weakly bound transition metals in the active sites of metalloenzymes if left unregulated. The ver- tebrate innate immune system uses several strategies to exploit this ?Achilles heel? of microbial physiology, but bacterial evolu- tion has responded in kind. This review highlights recent insights into transcriptional, transport, and trafficking mecha- nisms that pathogens use to ?win the fight? over zinc and thrive in an otherwise hostile environment.