INVESTIGADORES
CAPDEVILA Daiana Andrea
artículos
Título:
Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c
Autor/es:
DAIANA CAPDEVILA; DAMIAN ALVAREZ PAGGI; MARIA ANA CASTRO; VERONICA TORTORA; VERONICA DEMICHELI; DARIO ESTRIN; RAFAEL RADI; DANIEL MURGIDA
Revista:
CHEMICAL COMMUNICATIONS
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Lugar: CAMBRIDGE; Año: 2014 vol. 50
ISSN:
1359-7345
Resumen:
Here we report a spectroscopic, electrochemical and computational study of cytochrome c showing that nitration of Tyr74 induces Tyr deprotonation, which is coupled to Met/Lys axial ligand exchange, and results in concomitant gain of peroxidatic activity at physiological pH.
