Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives

GHIANO, DIEGO G.; DE LA IGLESIA, AGUSTINA; LIU, NINA; TONGE, PETER J.; MORBIDONI, HÉCTOR R.; LABADIE, GUILLERMO R.

EUROPEAN JOURNAL OF MEDICAL CHEMISTRY

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

Lugar: Amsterdam; Año: 2017 vol. 125 p. 842 - 852

0223-5234

A collection of 1,2,3-triazoles unsaturated fatty acid mimics were efficiently synthesized by click chemistry. The 1,4-disubstituted analogs prepared covered different alkyl chain lengths and triazole positions. The compounds were subsequently tested against Mycobacterium tuberculosis, being most of them active with some of the analogs displaying activity at micromolar concentration. The most potent member of the series has the triazole moiety on the C-2 position with a carbon chain of eight or ten carbon atoms. The 1,5-isomers of the most active analog were significantly less active than the original isomer. The activity of the selected hit was assayed on several clinical MTB multi-drug resistant strains providing the same MIC.