INVESTIGADORES
LABADIE Guillermo Roberto
artículos
Título:
A Simple Synthesis of a Model of the Tetracyclic Bisketal Lactone Mainframe of Saudin
Autor/es:
GUILLERMO ROBERTO LABADIE; LILIANA E. LUNA; RAQUEL MARIA CRAVERO; MANUEL GONZALEZ SIERRA
Revista:
HELVETICA CHIMICA ACTA
Editorial:
Verlag Helvetica Chimica Acta AG
Referencias:
Lugar: Zurich; Año: 2006 vol. 89 p. 2732 - 2737
ISSN:
0018-019X
Resumen:
The partial structure 2 of the bisketal-type, tetracyclic saudin (1), an important natural product, wasde novo synthesized. A key step was the Jones oxidation of the epoxide 3, which gave rise to epoxide-ring opening, followed by acetal hydrolysis, alcohol oxidation, and, finally, intramolecular acetal formation. The resulting key intermediate was finally oxidized to the target lactone 2.
