INVESTIGADORES
LABADIE Guillermo Roberto
artículos
Título:
Parallel solid supported synthesis of substituted dihydroxybenzylamines libraries with antileishmanial activity.
Autor/es:
GUILLERMO R. LABADIE; PAULO B. CARVALHO; SANJAY BATRA; SEOUNG-R CHOI; SHABANA I KHAN; BABU L. TEKWANI; MITCHELL A. AVERY
Revista:
Medicinal Chemistry Research
Editorial:
Birkhauser Boston
Referencias:
Lugar: Cambridge; Año: 2005 vol. 14 p. 332 - 346
ISSN:
1054-2523
Resumen:
A concise solid-supported parallel synthesis of 64 compounds is described. Starting with isovanillin, a two-step sequence involving reductive amination and N-benzylation was performed to provide the compounds in good purity. The library has been tested against Leishmania donovani and Plasmodium falciparum, with activity at the micromolar level.