INVESTIGADORES
LABADIE Guillermo Roberto
artículos
Título:
Targeting tuberculosis through a small focused library of 1,2,3-triazoles.
Autor/es:
GUILLERMO R. LABADIE; AGUSTINA I. DE LA IGLESIA; HECTOR R. MORBIDONI
Revista:
MOLECULAR DIVERSITY
Editorial:
SPRINGER
Referencias:
Año: 2011 vol. 15 p. 1017 - 1024
ISSN:
1381-1991
Resumen:
Looking for new active molecules against Mycobacterium tuberculosis a small focused library of 1,2,3-triazoles was efficiently prepared by click chemistry. Compounds were subsequently tested against different pathogenic and opportunistic mycobacteria including M. avium and M. tuberculosis. Two of them showed MIC at lower mg/mL concentration for M. avium and even below that for M. tuberculosis, being more potent that control drugs.