Comparison between the effects of flavonoids on arsenite-treated tumoral and non-tumoral cells

SORIA EA; EYNARD AR; BONGIOVANNI GA

Rosario (Argentina)

Congreso; XLII Reunión Anual de la SAIB; 2006

Objective: To study the effect of flavonoids on membrane of arsenite treated breast adenocarcinoma cells (MCF-7, ZR-75-1). Methods: Cells were incubated for 2 hours, with and without recovery (2 hours). Treatments: 200 µM NaAsO2 (As), 5 µM silymarin (S), 50 µM quercetin (Q), As+S, As+Q and controls (C). They were assayed for g-glutamyltranspeptidase activity (GGT), conjugated dienes measurement (CD) and sialic acid content (SA). Significant correlation coefficients were 0.5 (direct). Results were analyzed by ANOVA followed by the Tukey test (p