Development of an immunologic paraneoplastic syndrome in a lung adenocarcinoma modulated by dietary lipids.

PIEGARI M; SORIA EA; EYNARD AR; VALENTICH MA

Huerta Grande (Argentina)

Jornada; XVII Jornadas de la Sociedad de Biología de Córdoba; 2009

Tumour and immune parameters were analyzed by linear regression in mice with lung cancer under diets with corn, fish or olein oils. Although diet affected the T lympho-proliferation (TLP) and survival, the found paraneoplastic syndrome (anaemia, neutrophilia, splenomegaly, thymus atrophy and cachexia) behave independent of the diet. The tumour diameter (TD) was indirect to spleen weight (SW), and to basal and ConA-stimulated TLP, whereas tumour weight (TW) was direct. TLP was positively associated with the SW/body weight (BW) ratio and negatively with the thymus/body weight ratio. Spleen and thymus weights were indirectly associated. BW decreased with disease progression, being splenomegaly a negative factor and thymus weight a positive one. Thus, TD was a better prognostic marker than the TW (may relate to histological differences), being linked to survival and T response. The thymus associated with decreasing TD was a marker of the general status. Summing up, the lung cancer had a strong immunomodulating activity, of which parameters mutually interacted, giving identity to a paraneoplastic syndrome, where the thymus-dependent immunity may play a critical role.