INVESTIGADORES
PRIETO Maria Jimena
congresos y reuniones científicas
Título:
PAMAM Dendrimers Enhance the Solubility of Curcumin in Aqueous Media through Complexation in their Internal Pockets
Autor/es:
DANIELA IGARTÚA; CAROLINA MARTINEZ; SILVIA DEL V. ALONSO; M. JIMENA PRIETO
Lugar:
La Plata
Reunión:
Congreso; XLVII Reunión Anual de la Sociedad Argentina de Biofísica.; 2018
Institución organizadora:
Sociedad Argentina de Biofísica.
Resumen:
Curcumin (CUR) is a natural polyphenol derived from the turmeric Curcuma longa, which is used as a spice, food coloring, and medicine in oriental practices. CUR hasmultiple mechanisms of action that could modulate the Alzheimer´s Disease progression: (a) inhibits acetylcholinesterase enzyme; (b) inhibits the formation of aggregates of Aβand promotes the disintegration of those already formed; (c) inhibits TAU phosphorylation; and (d) acts as an antioxidant and anti-inflammatory, reducing levels of oxidativestress. However, clinical studies did not have positive results, which could be due to CUR insolubility in aqueous solutions, short half-life, photosensitivity, and lowbioavailability. For the aforementioned, the CUR is a candidate to be used in drug delivery systems. PAMAM dendrimers (D) generation 4.0 and 4.5 (DG4.0 and DG4.5) arepolymers that would increase the solubility of hydrophobic drugs. The present work aimed to obtain and characterize complexes between CUR and PAMAM dendrimers.