INVESTIGADORES
PRIETO Maria Jimena
congresos y reuniones científicas
Título:
Ecotoxicology of nanoparticles: Relation between biophysical properties of nanostructures and their toxicity on zebrafish
Autor/es:
M. J. PRIETO; C. MARTINEZ; DANIELA E. IGARTUA; NADIA S. CHIARAMONI; SILVIA DEL V. ALONSO
Reunión:
Conferencia; ICGEB-LAZEN: V Latin American Zebrafish Network Course and Symposium; 2018
Resumen:
In recent years, the use of commercial nanoparticles in different industry and health fields has increased exponentially. However, the uncontrolled application of nanoparticles might present a potential risk to the environment and health. Since the physicochemical properties of the compounds vary when they are produced at nanoscale, and that the environmental systems are dynamic, it is not possible to predict the hazards associated with the release of nanomaterials into the environment both for human and ecosystem health. So, it is necessary to carry out a comprehensive analysis of the toxicity of water and effluents by studying the behavior of new technologies in ecosystems.Zebrafish were used as biomarkers due to their short development times. Tests done were acute toxicity (mortality), teratogenicity (hatching rate and morphology), general developmental anomalies and tissue-specific toxicity (morphology and functioning of brain, heart and liver).We evaluated the toxicity of different micro- and nanoparticles (carbon nanotubes, dendrimers, emulsions, liposomes, metal nanoparticles, and solid lipid nanoparticles) associated to their biophysical properties using this model. The main biophysical properties studied are size, charge and surface potential due to their impact on the environment and health effects. The observed the correlation of the effects of the different nanoparticles on zebrafish. Special focus was made on morphological abnormalities, altered development and abnormal behavior.