ZEBRAFISH LARVAE AS A MODEL TO STUDY THE BIOCOMPATIBILITY OF FOLIC ACID MAGNETIC NANOTHERANOSTICS DELIVERING DOXORUBICIN

DANIELA EDITH IGARTÚA ; PAMELA LILIANA AZCONA; CAROLINA SOLEDAD MARTINEZ; SILVIA DEL VALLE ALONSO; VERÓNICA LETICIA LASSALLE; MARÍA JIMENA PRIETO

Cuernavaca

Simposio; ICGEB-LAZEN: V Latin American Zebrafish Network Course and Symposium; 2018

Magnetic nanoparticles (MNPs) allow drug targeting to a specific tissue or organ by the influence of an external magnetic field. The modification of the surface with both biological and drug molecules, in addition to their ability to act as contrast agents in RMI, turn these nanosystems as theranostics. The functionalization of MNPs surface with folic acid (MNPs@FA) improves specific targeting, ensuring the uptake by cancer cells that overexpress the FA receptor. Doxorubicin (DOXO) is a chemotherapeutic agent widely used for the treatment of solid tumors and hematologic malignancies in both adults and children. However, it causes short- and long-term cardiotoxicity and others undesirable side effects, as nephrotoxicity and neurotoxicity. In this way, the incorporation of DOXO to MNPs@FA would ensure therapeutic targeting and lead to a decrease in its side effects (MNPs@FA@DOXO).