Toxicity evaluation of doxorubicin-loaded mixed micelles on larvae of zebrafishToxicity evaluation of doxorubicin-loaded mixed micelles on larvae of zebrafish

MARIA NATALIA CALIENNI; CARLOS MAXIMILIANO CAGEL; MARIA JIMENA PRIETO; MARCELA A MORETTON; SILVIA DEL VALLE ALONSO; DIEGO ANDRES CHIAPPETTA; JORGE MONTANARI

Cuernavaca

Simposio; ICGEB-LAZEN: V Latin American Zebrafish Network Course and Symposium; 2018

Doxorubicin hydrochloride is a powerful anthracycline antibiotic used for the treatment of various types of malignancies, particularly ovarian and metastatic breast cancer. However, doxorubicin presents severe side effects, such as hepatotoxicity, brain damage, and cardiotoxicity. We have previously designed doxorubicin-loaded mixed micelles composed of D-α-tocopheryl polyethylene glycol 1000 succinate and Tetronic® T1107, demonstrating an enhanced in vitro antitumoral efficacy versus Doxil® in breast and ovarian human cancer cell lines. Nevertheless, additional studies to assess the potential toxic effects of micellar formulations were needed.