INVESTIGADORES
PRIETO Maria Jimena
congresos y reuniones científicas
Título:
PAMAM Dendrimers as an efficient Carbamazepine Delivery System: Nanotoxicological Characterization
Autor/es:
DANIELA E. IGARTÚA; CAROLINA S. MARTINEZ; SILVIA DEL V. ALONSO; M. JIMENA PRIETO
Lugar:
Buenos Aires
Reunión:
Congreso; Reunión Conjunta de Sociedades de BioCiencias. Buenos Aires, Argentina.; 2017
Institución organizadora:
SAIC/SAB/SAIB
Resumen:
Carbamazepine (CBZ) is on the market as an antiepileptic. It also has potential uses for the treatment of numerous neurodegenerative diseases. However, it has low solubility in aqueous media, inefficient pharmacokinetic profiles and multiple side effects, so it is important to avoid widespread distribution. Drugs delivery systems (DDS) have gained relevance in the field of nano- and bio-medicines. PAMAM dendrimers G4.0 and G4.5 are optimal polymers as DDS that would increase the solubility of CBZ and the arrival to the brain. Our objective was to characterize complexes between CBZ and dendrimers and to study their nanotoxicity.
