DEVELOPMENT, BIOPHYSICAL AND TOXICICAL CHARACTERIZATION OF POLYMERIC NANOPARTICLES

PATRICIO, B.F.C.; PRIETO, M. J; FEAS, D; MARTINEZ, C.; ALONSO, S. V. ; BISCH, P. M.; WEISSMÜLLER, G

San Pablo

Congreso; Congreso de Federação de Sociedades de Biologia Experimental (FeSBE).; 2015

Federação de Sociedades de Biologia Experimental

The use of nanoparticles as drug carriers promises properties such as controlled, prolonged and sustained release of the active ingredient, reduction of the required dose for therapeutic effect and the toxic effects. In addition, it is well known that in inflamed tissue,the endotelium possess around 250 nm gaps between cells, so particles with size between 4-250 nm will deliver the therapy through the unhealthy endothelium only. However this kind of therapy requires a toxicological study.The use of zebrafish (Danio rerio) to study acute and chronic toxicity of drug and nanoparticles are growing. They are relatively easy to use and give a first idea of the biodistribution of the nanoparticles.The aim of this study is to produce polymeric nanoparticles, evaluating the parameters in relation to the size of the nanoparticles.