INVESTIGADORES
PRIETO Maria Jimena
congresos y reuniones científicas
Título:
Nanotoxicology characterization of carbamazepine-dendrimers complexes
Autor/es:
IGARTÚA, DE; MARTINEZ, CS; ALONSO, SDV; PRIETO, MJ
Lugar:
Porto Alegre
Reunión:
Simposio; LatinAmerican Zebrafish Network (LAZEN) Symposium.; 2016
Institución organizadora:
Lazen
Resumen:
Carbamazepine (CBZ) is on the market as an antiepileptic. It also has potential uses for the treatment of numerous neurodegenerative diseases. However, it has low solubility in aqueous media, inefficient pharmacokinetic profiles and multiple side effects, so it is important to avoidwidespread distribution. Drugs delivery systems (DDS) have gained relevance in the field of nanoand bio-medicines. PAMAM dendrimers (D) generation 4.0 and 4.5 (DG4.0 and DG4.5) are optimal polymers as DDS that would increase the solubility of CBZ and the arrival to the brain.Our objective was to characterize complexes between CBZ and dendrimers (D-CBZ) and to study their nanotoxicity for both human health and environmental risk during production