INVESTIGADORES
CHOI Marcelo Roberto
congresos y reuniones científicas
Título:
Effects of metformin on blood pressure in high-fat diet fed rat
Autor/es:
LEE HJ; SANCHEZ ELUCHANS N; CANTÚ SM; CHOI MR; DONOSO AS; PEREDO H; PUYÓ AM
Lugar:
Seoul
Reunión:
Congreso; 26th Scientific Meeting of the International Society of Hypertension; 2016
Institución organizadora:
International Society of Hypertension
Resumen:
Objective: Metabolic and cardiovascular diseases are closely linked. A high-fat(HF) diet produces in the rat insulin resistance which is related to cardiovascularalterations such as hypertension. Metformin (Mf) is a fi rst-line oral therapy fortype 2 diabetes and metabolic syndrome. The aim of this study was to analyzethe effect of Mf on blood pressure (BP), metabolic parameters, mesenteric vascularbed (MVB) prostanoids (PR) production and morphometry of the abdominalaorta (AA) in male Sprague-Dawley rats under a HF diet.Design and method: Four groups were studied during 12 weeks: Control (C),standard diet (SD); HF diet (HF), 50% (w/w) bovine fat added to SD; C+Mf(CMf) 500 mg/Kg/day and HF+Mf (HFMf). PR were determined by HPLC. AAmorphometry by image analysis.Results: HF diet increased body weight (BW) gain (g), 264 ± 8 vs. 198 ± 10.p < 0.001; MVBweight/BW ratio 1.72 ± 0.1 vs. 0.8 ± 0.1, p < 0.001; glycemiaand triglyceridemia (mg/dl), 144 ± 4 vs. 127 ± 4 p < 0.05; 166 ± 21 vs. 86 ± 9,p < 0,01, respectively; systolic BP (mmHg), 151 ± 2 vs. 127 ± 2, p < 0,001;thromboxane (TX) B2 release (ng PR/mg tissue) 125 ± 9 vs. 71 ± 6, p < 0,05;prostaglandin (PG) F2alpha (ng/mg), 166 ± 11 vs. 87 ± 9, p < 0,05 and AA wallthickness (WT)/lumen diameter (LD) ratio (mm/mm), 6.4 ± 0.4 vs. 4.8 ± 0.3p < 0.05. In HFMf group BW gain, 183 ± 27 vs. 264 ± 8 p < 0.05; MVBweight/BW ratio (1.38 ± 0.1 vs. 1.72 ± 0.8, p < 0.05); glycemia and triglyceridemia (mg/dl, 110 ± 11 vs. 144 ± 4; 65 ± 13 vs. 166 ± 21, p < 0.05); systolic BP (141 ± 1vs. 151 ± 2, p < 0.01); TXB2 release (49 ± 3 vs. 125 ± 9, p < 0.05); PG F2alpharelease (81 ± 13 vs. 166 ± 11, p < 0.01); and AA WT/LD ratio, 5.4 ± 0.1 vs.6.4 ± 0.4, p < 0.05 were decreased compared to HF.Conclusions: These results suggest that Mf lowers BP by decreasing peripheralvascular resistance, which could be attributed, at least in part, to the decreasedrelease of vasoconstrictors PR in the MVB as well as by a reduced vascular remodelingin the AA.