Natriuretic Peptide Receptor Type C

KOUYOUMDZIAN NM; RUKAVINA MIKUSIC NL; LEE HJ; FERNÁNDEZ BE; CHOI MR

Encyclopedia of Signaling Molecules

Springer

Año: 2018; p. 3355 - 3361

NPRC has traditionallybeen considered a clearance receptor of NPs responsible forreceptor-mediated degradation of these peptides. In the last years, this view hasbeen overcome by several studies showing evidence of NPRC multiple effects ondifferent cells and organs and of the existence of a specific intracellularmechanism of action. These effects would be mediated by CNP stimulation ratherthan by ANP and BNP. A main role on vascular, cardiac and metabolic physiologyand on bone turnover has been proposed. Many studies indicate that alterationsof NPRC function and structure as well as the existence of gene polymorphismswould be implicated in the pathophysiology of several diseases. Furtherinvestigation is needed to completely elucidate the physiological role playedby NPRC and also to understand how NPRC alterations at gene and protein levelcould contribute to the development of pathological states as a cause ofnatriuretic system disruption.