POTENTIAL ROLE OF INTERLEUKIN 10 ONTHE EFFECTS OF FENOFIBRATE IN AN EXPERIMENTAL MODEL OF CHAGAS DISEASE

RADA, MARIA JIMENA; DONATO, MARTIN; PIERALISI, AZUL; CEVEY, AGATA CAROLINA; PENAS, FEDERICO N.; GELPI, RICARDO; ALBA SOTO, CATALINA D.; MIRKIN, GERARDO ARIEL; GOREN, NORA B.

Mar del Plata

Congreso; LXVI Reunión Anual Sociedad Argentina de Investigación Clínica SAIC 2019.; 2019

Sociedad Argentina de Investigación Clínica

POTENTIAL ROLE OF INTERLEUKIN 10 ONTHE EFFECTS OF FENOFIBRATE IN AN EXPERIMENTAL MODEL OF CHAGAS DISEASE.Maria Jimena RADA (1) | Martín DONATO(2) | Azul Victoria PIERALISI(1) | Ágata Carolina CEVEY(1) | Federico Nicolás PENAS(1) | Ricardo J GELPI(2) | Catalina ALBA SOTO(1) | Gerardo Ariel MIRKIN(3) | Nora Beatriz GOREN(1)Abstract/Resumen: Chagas disease, caused by Trypanosoma cruzi (Tc) infection, is conditioned by the presence of the parasite and the development of an inflammatory response. PPARa ligands, such as fenofibrate (fen) modulate inflammation and restore ventricular function. Interleukin 10 (IL10) is produced by a variety of cells and plays an important role in the resolution of inflammatory processes. We evaluated the potential role of IL10 in the effects of fen on the modulation of the immune response and on cardiac remodeling and function, in BALB/c IL10 knockout (IL10-/-) mice infected with a non-lethal Tc strain. The ejection fraction (EF) and the shortening fraction (SF) were measured by echocardiography, which were diminished in Tc in comparison with uninfected mice (p