Metformin prevents renal sodium retention and blood pressure increase in rats exposed to chronic high fat diet

DONOSO AS; LEE HJ; PUYÓ AM; VAGO R; CANTÚ SM; TRIDA VA; CHOI MR

Virtual

Congreso; Reunión Anual de Sociedades de Biociencias (SAIC-SAI-SAFIS 2020); 2020

SAIC-SAI-SAFIS

Kidneys are sensitive to high fat diet (HFD) showing intracellular lipid accumulation, tubular atrophy, interstitial fibrosis and glomerulosclerosis. Metformin, a biguanide drug, is mainly use for insulin resistance therapy. The aim of this study was to analyze the preventive effect of 8 weeks metformin therapy over sodium excretion, systolic blood pressure (SBP), and renal tissue integrity in male Sprague-Dawley rats under HFD. The animals (body weight of 180-200 gr) were randomized on 4 groups (n=4/each one): control (C, standard diet and tap water to drink), HFD (C + 50% w/w fat added to C diet), control+metformin (CM, C + 500mg/kg/day of metformin diluted in the water), HFD+metformin (HFDM, HFD+CM). Results: Metformin improved fractional sodium excretion (FENa%, HFDM: 0.34±0.09 vs HFD: 0.16±0.02; p