Precision Medicine in the Renin Angiotensin System Therapeutic Targets and Biological Variability

GUILLERMO A KELLER; DI GIROLAMO GUILLERMO; DI SALVO HE; FERREIRÓS GAGO MARÍA LAURA

Curr Drug Targets

Bentham Science Publishers

Lugar: Saif Zone, Sharjah, U. A. E. ; Año: 2020

Abstract: Pathologies linked to the renin angiotensin system are frequent, and the drugs used in them are numerous and show great variability in therapeutic effects and adverse reactions. Genetic variants have been detected in the angiotensinogen gene (6), angiotensin converting enzyme (9), Angiotensin converting enzyme 2 (1), and angiotensin receptor Type 1 (4) among others. However, the large number of studies that have analyzed each of them makes it complex and almost impossible to consider all the existing information. This manuscript aims to review the effects of the different known variants on the expected response of different drugs as a basis for the future development of therapeutic guidelines that seek to implement therapeutic individualization strategies on the renin angiotensin system.