Liver resident natural killer and T cells

PODHORZER ARIEL; MACHICOTE ANDRÉS; FAINBOIM LEONARDO; BAZ PLÁCIDA

Viena

Congreso; 4th European Congress of Immunology; 2015; 2015

Most immunological studies on NK cells and T cells have focused on peripheral blood (PB) cells. The present study aimed to investigate liver microenvironment and determine differences between liver and peripheral blood (PB) NK and T cells. Material and Methods: NK receptors and T cells differentiation markers were analyzed on MNCs from PB healthy controls (N=32) or from liver perfusion collection from donor livers (N=10) The expression of surface markers was detected by flow cytometry Results: In comparison with PB, liver residentNK cells show increased frequencies of NKbright : 18% Vs 0.8