PERSONAL DE APOYO
BAZ Placida
artículos
Título:
Regulatory and effector T-cells are differentially modulated by Dexamethasone
Autor/es:
LOURDES ARRUVITO; LEONARDO FAINBOIM; LUIS ARIEL BILLORDO; JULIETA PANDOLFI; PABLO FERNÁNDEZ; PLÁCIDA BAZ
Revista:
CLINICAL IMMUNOLOGY
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 2013 p. 400 - 400
ISSN:
1521-6616
Resumen:
It is assumed that the ratio between effector T cells (Teff) and regulatory T cells (Tregs) controls the immune reactivity within the T-cell compartment. The purpose of this study was to investigate if Dexamethasone (Dex) affects Teff and Tregs subsets. Dex induced on Tregs a dose and time-dependent apoptosis which resulted in a relative increase of Teff. After TCR activation, Dex induced a strong proliferative inhibition of Teff, but a weaker proliferative inhibition on Tregs. These effects were modulated by IL-2, which not only restored the proliferative response, but also prevented Dex-induced apoptosis. The highest dose of IL-2 prevented apoptosis on all FOXP3 + CD4+ T cells. Meanwhile, the lowest dose only rescued activated Tregs (aTregs), probably related to their CD25 higher expression. Because Dex did not affect the suppressor capacity of aTregs either, our results support the notion that under Dex treatment, the regulatory T-cell compartmentmaintains its homeostasis.