LOW TLR9 EXPRESSION IN ADAPTIVE CELLS PROTECTS AGAINST PROGRESSION OF NONALCOHOLIC FATTY LIVER DISEASES

NADIA S. ALEGRE; CECILIA C. GARCIA; LUIS A. BILLORDO; JAVIER BENAVIDES; LUIS COLOMBATO; DANIEL PONCINO; DANIEL GARCÍA; ALEJANDRA C. CHERÑAVSKY

Ámsterdam

Congreso; Annual meeting- The international Liver Congress 2017; 2017

EASL

Introduction: T cells play a key role on the progress of nonalcoholic fatty liver disease (NAFLD). Signaling through Toll-likereceptors (TLRs)co-stimulates the activaation, differentiation and generation of memory T cells.No study correlates clinical facts inNAFLD with TLR expression and function of adaptive cells.Aims: To study the potential link between TLR9 expression in peripheral and hepatic adaptive cells and the consequences of TLR9expression onn the co-stimulatory activity and genertion of peripheral memory T cells.Conclusions: A global decrease of TLR9 expression in adaptive cells is linked todistinctive metabolic changes associated with NAFLD. In addition, the relation described between T cell activation and TLR9 expression evidences its protective role against an increased differentiation of CD8+ cells at early stages of NAFLD progression