PERSONAL DE APOYO
BILLORDO Luis Ariel
congresos y reuniones científicas
Título:
Low TLR9 expression in CD4 + and CD8 + human peripheral blood cells might play a role in NAFLD
Autor/es:
ALEGRE NS; GARCÍA CC; LUIS A. BILLORDO; BENAVIDEZ J; COLOMBATO L; FRÍAS S; AMEIGEIRAS B; ALEJANDRA CLAUDIA CHERÑAVSKY
Lugar:
Mar del Plata
Reunión:
Encuentro; LXIV Reunión Anual de la Sociedad Argentina de Inmunología; 2016
Institución organizadora:
Sociedad Argentina de Inmunología
Resumen:
Liver exposure to intestinal-derived bacterial products promotes a pro-inflammatory milieu that induces innate immunity and contributes to thepathogenesis of nonalcoholic fatty liver disease (NAFLD) via pattern-recognition receptors such as Toll-like receptors (TLRs). TLRs are expressed in T cellsand co-stimulate its activation. Particularly, TLR9 recognize bacterial DNA and is involved in Kupffer cell activation leading to nonalcoholicsteatohepatitis. Aims: To evaluate TLR9 expression in peripheral blood (PB) and liver infiltrating T cells from NAFLD patients and healthy donors, and Itsco-stimulatory role in circulating T cells.
