PERSONAL DE APOYO
BILLORDO Luis Ariel
artículos
Título:
Identification and clinical relevance of naturally occurring human CD8+HLA-DR+ regulatory T cells
Autor/es:
LOURDES ARRUVITO; FLORENCIA PAYASLIÁN; PLÁCIDA BAZ; ARIEL PODHORZER; LUIS ARIEL BILLORDO; JULIETA PANDOLFI; GUILLERMO SEMENIUK; EDUARDO ARRIBALZAGA; LEONARDO FAINBOIM
Revista:
JOURNAL OF IMMUNOLOGY
Editorial:
AMER ASSOC IMMUNOLOGISTS
Referencias:
Lugar: Bethesda; Año: 2014
ISSN:
0022-1767
Resumen:
The lack of responsiveness to self and non-self antigens is normally maintained by multiple mechanisms, including the suppressive activities of several T cell subsets. Here, we show that CD8+ T cells from both adult peripheral blood and umbilical cord blood mononuclear cells constitutively expressing HLA-DR represent a natural human CD8+ regulatory T cell subset (Tregs). Their suppressive effect appears to be cell-to-cell contact-dependent and may involve CTLA-4 signaling between neighboring T cells. These Tregs can be expanded in vitro and exhibit a suppressive capacity similar to that observed in ex vivo CD8+HLA-DR+ T cells. Moreover, the high frequency of CD8+HLA-DR+ Tregs we detected in patients with non-small-cell lung cancer strongly suggests that they may play a central biological role in the poor prognosis of these patients.