INVESTIGADORES
FENOY Ignacio Martin
congresos y reuniones científicas
Título:
Immune-modulatory properties of the Toxoplasma gondii serine protease inhibitor-1 (TgPI-1)
Autor/es:
SANCHEZ V; FENOY, I; PICCHIO M; SOTO A; GOLDMAN A; MARTIN V
Reunión:
Congreso; LXI Reunión anual de la sociedad Argentina de Inmunología; 2013
Resumen:
Toxoplasma gondii serine protease inhibitor 1 (TgPI-1) is a potent inhibitor of neutrophil elastase, trypsin and chymotrypsin in vitro. It has been shown that other serine protease inhibitors are able to modulate the immune system. In this work we studied the in vitro effects of rTgPI-1 on T helper modulation during an adaptive immune response with Th1 or Th2 profiles and on naïve cells. To assess the modulation of a Th2 response, we used a mouse model of allergy with OVA antigen as allergen. BALB/c mice were sensitized by 2 ip OVA/Al(OH)3 and then aerosol challenged with OVA 3%. Splenocytes from allergic mice were in vitro treated with OVA or OVA+rTgPI-1. The results showed that rTgPI-1 (PI) induced a significant decrease in IL-5 (OVA: 307±46; OVA+PI: 191±30; pg/ml±SEM, p