INVESTIGADORES
FENOY Ignacio Martin
artículos
Título:
Regulatory cells induced by acute toxoplasmosis prevent the development of allergic lung inflammation
Autor/es:
FENOY, I; SÁNCHEZ V; SOTO A; PICCHIO M; MAGLIOCO A; CORIGLIANO M; DRAN G; MARTIN V; GOLDMAN A
Revista:
IMMUNOBIOLOGY.
Editorial:
ELSEVIER GMBH
Referencias:
Año: 2014
ISSN:
0171-2985
Resumen:
Abstract: The increased prevalence of allergies in developed countries has been attributed to a reduction of some infections. Supporting epidemiological studies, we previously showed that both acute and chronic T. gondii infection can diminish allergic airway inflammation in BALB/c mice. The mechanisms involved when sensitization occurs during acute phase would be related to the strong Th1 response induced by the parasite. Here, we further investigated the mechanisms involved in T. gondii allergy protection in mice sensitized during acute T. gondii infection. Adoptive transference assays and ex vivo co-cultures experiments showed that not only thoracic lymph node cells from infected and sensitized mice but also from non-sensitized infected animals diminished both allergic lung inflammation and the proliferation of effector T cells from allergic mice. This ability was found to be contact- independent and correlated with high levels of CD4+FoxP3+ cells. IL-10 would not be involved in allergy suppression since IL-10-deficient mice behaved similar to wild type mice. Our results extend earlier work and show that, in addition to immune deviation, acute T. gondii infection can suppress allergic airway inflammation through immune suppression.