ICIAGRO-LITORAL 28228
INSTITUTO DE CIENCIAS AGROPECUARIAS DEL LITORAL
Unidad Ejecutora - UE
artículos
Título:
In vivo tumor growth inhibition by Solanum tuberosum aspartic protease 3 (StAP3) treatment
Autor/es:
IBAÑEZ, INÉS; ABAURREA, RICARDO; GUEVARA, MARÍA GABRIELA; MUÑOZ, FERNANDO; SCANDOGLIERO, EDUARDO; ZOPPI, JORGE; DURÁN, HEBE
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2021 vol. 41
ISSN:
0960-894X
Resumen:
Solanum tuberosum aspartic Proteases (StAPs) show selective plasma membrane permeabilization, inducing cytotoxicity of cancer cells versus normal cells in vitro. Herein, we aimed to evaluate both StAP3 systemic toxicity and antitumoral activity against human melanoma in vivo. The toxicity of a single high dose of StAP3 (10 µg/g body weight, intraperitoneally) was assessed in a Balb/c mice model. Subcutaneous A375 human melanoma xenografts in athymic nude (nu/nu) mice were induced. Once tumors developed (mean larger dimension=3.8 ± 0.09 mm), mice were StAP3-treated (6 µg/g body weight, subcutaneously under the tumor at a single dose). For both models, controls were treated with physiologic saline solution. StAP3-treated mice showed a significant inhibition of tumor growth (p
