FRACCAROLI Laura Virginia
capítulos de libros
An immunopharmacological view on the maternal-fetal early interaction under physiological and pathological conditions.
R. RAMHORST; V. ROCA; L. LAROCCA; L. FRACCAROLI; J. ALFIERI; C. PÉREZ LEIRÓS
Inflammatory mediators involved in normal and pathological pregnancies
Research Sign post Eds.
Año: 2010; p. 67 - 82
Early pregnancy challenges a variety of cells and molecules from the mother and the embryo that need to concur and to interact efficiently for a successful implantation. Given the poor understanding of the precise mechanisms underlying unexplained recurrent pregnancy loss, therapy so far has been empirical and not evidence-based. The progress in the comprehension of maternal immunotolerance to fetal antigens in health and disease might provide clues to the identification of drug targets among newly defined biochemical mediators and/or within cellular and molecular interactions. In this regard, the ability to translate pathophysiological into immunopharmacological information could help to the rationale of innovative therapeutic strategies. To contribute to that objective, the design of experimental in vitro models for drug screening is also needed. Here we have reviewed the literature on the pathophysiological mechanisms and mediators of the maternal-fetal interface focusing on the main characters in each section. Then, following each cell or circuit description, we have provided information on results from current therapies related to those cells and circuits with the aim of contributing to the identification of new targets for drug design and intervention. A final statement with the potential of co-cultures for drug screening is also included.