INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
In C. elegans, alterations in neuronal membrane glycoprotein 1 (nmgp-1) impairs dauer recovery, egg-laying and chemosensation
BROCCO MARCELA; MONTELEONE MELISA; FERNANDEZ ELIANA MAILEN; CUTRARO YAMILA
Congreso; Second Latin maerican Worm Meeting; 2020
Depression affects millions of people in the world. This disorder has a multifactorial etiology that hinders its study. However, we know that chronic stress is a key factor in its development.Using several models of chronic stress, our group found that M6a neuronal protein levels are modified in stressed individuals. Although we established that M6a participates in neuronal plasticity and synaptogenesis, we still do not know the relationship between its cellular functions and its role in the stress response. To investigate this, we take advantage of the Caenorhabditis elegans model worm that expresses NMGP-1, M6a ortholog. We found that worms deficient in NMGP-1 have alterations in behaviors that depend on the detection of the environment such as survival, egg laying and recovery of the dauer stage. In addition, some sensory neurons have an abnormal morphology. This suggests that NMGP-1 participates in neuronal morphogenesis and environmental perception, fundamental processes to respond to stress. Altogether, this information could allow us to understand the involvement of NMGP-1 / M6a in the stress response.