DIETARY CALCIUM CONTENT INFLUENCES BODY COMPOSITION AND BONE MARKERS OF OBESE (BETA O)

MAROTTE C; WEISSTAUB A; HERNANDEZ E; PELLEGRINI G; PORTELA ML; GONZALES CHAVES M; ZENI SN

Glascow, Scotland

Congreso; 37 european calcified tissue simposium; 2010

ECTS

Abstract: According to recent literature, osteoporosis and obesity are interrelated. On these bases we had compared the effect of feeding different dietary calcium (Ca) levels on body weight (BW) and composition and its relationship to bone metabolism, in genetically modified obese (ƒÀ) rats during growth . Rats were mated and fed diets varying Ca content: high: 0.9% (ƒÀH); normal: 0.5% (ƒÀN); low: 0.2% (ƒÀL). A Wistar group was run simultaneously (W) as control and fed a diet according to AINL93. At weanling, the male pups continued feeding the same diet till 50 days of age. At the end of the experience, body composition, bone alkaline phosphatase (BAP), BGP and CTX (ELISA) were evaluated. ResultsAccording to recent literature, osteoporosis and obesity are interrelated. On these bases we had compared the effect of feeding different dietary calcium (Ca) levels on body weight (BW) and composition and its relationship to bone metabolism, in genetically modified obese (ƒÀ) rats during growth . Rats were mated and fed diets varying Ca content: high: 0.9% (ƒÀH); normal: 0.5% (ƒÀN); low: 0.2% (ƒÀL). A Wistar group was run simultaneously (W) as control and fed a diet according to AINL93. At weanling, the male pups continued feeding the same diet till 50 days of age. At the end of the experience, body composition, bone alkaline phosphatase (BAP), BGP and CTX (ELISA) were evaluated. ResultsResults (mean}SD): Food intake was similar in all groups. BW was lower in ƒÀH vs. ƒÀN and ƒÀH groups (162}18 vs. 217}31 221}37g; p<0.01). In ƒÀ groups ashes content (g/100g) increased as dietary Ca content increases (1.88}0.26; 2.42}0.24, 2.51}0.21; p<0.03) without reaching W values (2.71}0.21). Lipids% was higher in ƒÀL and ƒÀN (14.7}1.3 and 13.6}2.7) vs. W (10.9}2.6) and ƒÀH (12.6}2.2) (p<0.05). BAP (IU/L) did not show differences among ƒÀ groups (186}27, 193}39 and 184}30), being higher vs. W (67.8}10.0). BGP (ug/ml) exhibit an inverse correlation with dietary Ca level in ƒÀ (447}45, 375}46 and 279}73), being lower than W (825}106) (p<0.01). CTX (mg/ml) did not show differences between W (88}16) and ƒÀH (87}4) which were higher vs ƒÀN and ƒÀL (69}12 and 70}3, respectively) (p<0.01). Conclusions: The increase in dietary Ca content seems to decrease BW and body lipids content and to increase mineral content of ƒÀ rats. These findings together with changes in bone markers suggest an imbalance in bone metabolism related to adipose tissue. This abstract is part of C. Marote PhD. UBACyT B 091.Conclusions: The increase in dietary Ca content seems to decrease BW and body lipids content and to increase mineral content of ƒÀ rats. These findings together with changes in bone markers suggest an imbalance in bone metabolism related to adipose tissue. This abstract is part of C. Marote PhD. UBACyT B 091. Disclosure of Interest: None Declared: None Declared Keywords: obese rats - dietary calcium content - bone - fat: obese rats - dietary calcium content - bone - fat