Comparative effect of deproteinized bovine bone, bioglass and, synthetic hydroxyapatite on bone reparation.

MATTIUZZI AS; PELLEGRINI MA; GONZALES CHAVES MMS; ORZUZA R; ZENI SN; PELLEGRINI GG

Congreso; American Society for Bone and Mineral Research Annual Meeting; 2018

ASBMR

Deproteinized bovine bone putty (BB), bioglass (BG) and, synthetic hydroxyapatite (SH), (Synergy, Odontit Implant Systems, Argentina) guide bone repair because of their osteoconductive properties. The bone healing response of these bone-grafting materials was compared using a critical sized bone defect model. A bone defect of 4 mm diameter was created in rat tibiae for implantation with each biomaterial (N=30 rats). Samples for histological and histomorphometrical analysis of new bone formation (NBF) and remaining particles of each device (RP) were collected at 2 and 4 weeks. Results: Percentage (%) of NBF (mean ± SD): 2 weeks: Control group: 6.60±3.71; BB group: 23.23±3.89*; BG group: 18.35±5.23*; SH group: 26.27±9.30*; 4 weeks: Control group: 6.69±2.38; BB group: 24.37±3.66*; BG group: 17.45±6.64*; SH group: 32.25±3.80*. Percentage (%) of RP: 2 weeks: Control group: 0±0; BB group: 5.04±1.39*; BG group: 3.03±2.31*; SH group: 4.46±2.87*; 4 weeks: Control group: 0±0; BB group: 4.45±2.35*; BG group: 2.87±1.14*; SH group: 3.78±1.68* (*p