Alpha CTX levels and normal rate of growth.

PELLEGRINI GG; LINARI M; PIAZZA N; SOMOSA J; RIO ME; ZENI SN

Rosario, Argentina

Congreso; XXIV Reunión de la Asociación Argentina de Osteología y Metabolismo Mineral.; 2007

AAOMM

  As a result of cysteine proteinases´ activity, type I collagen is cleaved into several fragments which are released into circulation. Some of them, such as the C-terminal telopeptide of type I collagen (CTX) rearrangement, can be quantified by specific immunoassay. This motif derived from newly −CTX form, but with age is susceptible of á synthesized collagen is in the −CTX. The objective of the study was spontaneous nonenzymatic isomerization to −CTX levels in 313 healthy normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). nonenzymatic isomerization to −CTX levels in 313 healthy normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). nonenzymatic isomerization to −CTX levels in 313 healthy normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). the −CTX. The objective of the study was spontaneous nonenzymatic isomerization to −CTX levels in 313 healthy normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). nonenzymatic isomerization to −CTX levels in 313 healthy normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). nonenzymatic isomerization to −CTX levels in 313 healthy normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). the −CTX. The objective of the study was spontaneous nonenzymatic isomerization to −CTX levels in 313 healthy normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). nonenzymatic isomerization to −CTX levels in 313 healthy normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). nonenzymatic isomerization to −CTX levels in 313 healthy normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). form, but with age is susceptible of á synthesized collagen is in the −CTX. The objective of the study was spontaneous nonenzymatic isomerization to −CTX levels in 313 healthy normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were assessed; 20 premenopausal (37±8 years) and 20 postmenopausal women (58±5 years) where −CTX (ìg/ mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). mM creatinine) was determined in the 2nd void urine were studied. The −CTX were prepuberal á ELISA (AlphaCTX, Nordic Bioscience). Nordic Bioscience). Nordic Bioscience). nonenzymatic isomerization to −CTX levels in 313 healthy normal subjects. For this purpose, 173 prepuberal children (70 girls and 103 boys) and 30 adolescents (18 girls and 12 boy from 11 to 12 years) attending public schools (Vte Lopez, Bs. As., Argentina) were asses