PELLEGRINI Gretel Gisela
Preliminary study on the biocompatibility and osteoconductive properties of a new bovine bone graft.
PELLEGRINI G; GONZALES CHAVES M; ORZUZA R; ZENI S
Actualizaciones en Osteologia
To prevent post-extraction resorption and preserve the integrity of the alveolar ridges, the placement of bone grafts at the time of ex- traction is recommended. Bovine bone grafts are biocompatibile and osteoconductive, al- lowing new bone apposition by osteoprogeni- tor cells. Although there are trademarks recognized internationally regarding bovine bone grafts, they are expensive and even difficult to acquire. Therefore, domestic industry de- velopment of high quality biomaterials will reduce the public health high costs in the dental field. Here, we evaluated and compared the effects of an Argentinean manufactured bovine bone graft (Synergy Bone Matrix) with a bovine bone graft recognized for its osteo- conductive effects (Bio-Oss), on bone healing in an experimental model in rats. We created critical sized bone defects in rat tibiae and filled them with either one of the bovine bone grafts or control. Clinical responses, X-ray findings, bone mineral density, and histologi- cal parameters were evaluated. No abscess, encapsulation, suppuration or inflammation of lymphatic nodes were observed. Radiographi- cally, all implants were amalgamated to thesurrounding bony margins, suggesting proper healing. On the other hand, control tibiae exhibited no signs of recovery and remained either unfilled or showed fibrous tissue forma- tion. No statistical differences were observed in BMC and BMD between tibiae filled with Synergy Bone Matrix or Bio-Oss. Histologi- cal analysis revealed particles of both bone grafts surrounded by laminar bone tissue indi- cating osteoconductivity, without any inflam- matory sign. This preliminary study suggests that Synergy Bone Matrix, as well as Bio-Oss, present similar properties of biocompatibility and osteoconductivity.