PELLEGRINI Gretel Gisela
Effect of a combination GOS/FOS® prebiotic mixture and interaction with calcium intake on mineral absorption and bone parameters in growing rats.
BRYK G; ZENI CORONEL M; PELLEGRINI GG; MANDALUNIS P; RIO ME; PORTELA ML; ZENI SN
EUROPEAN JOURNAL OF NUTRITION
DR DIETRICH STEINKOPFF VERLAG
AIM: Increasing calcium intake is the most effective strategy for avoiding Ca deficit. However, if intake remains inadequate, improving Ca absorption becomes an important tool to optimize Ca homeostasis and bone health.PURPOSE: The effect of a mixture of GOS/FOS® 9:1 added to a normal- or low-Ca diets on Ca absorption and bone mineralization, density and structure was investigated, in a model of growing rats. Several colonic parameters to help support the findings were also evaluated.RESULTS: Weanling Wistar rats received one of the four experimental AIN-93G diets: C5: 0.5 % Ca; C3: 0.3 % Ca; P5: 0.5 % Ca + 5.3 % GOS/FOS®; P3: 0.3 % Ca + 5.3 % GOS/FOS® until 50 days (T = 50). At T = 50, lactobacillus and cecum weights were higher, whereas cecum pH was lower in P5 and P3 versus C5 and C3 (p