PELLEGRINI Gretel Gisela
Salivary bone turnover markers in healthy pre- and postmenopausal women: daily and seasonal rhythm.
PELLEGRINI GG; GONZALES CHAVES MMS; FAJARDO MA; TOYOS GI; LIFSHITZ FIMA; FRIEDMAN SM; ZENI SN
CLINICAL ORAL INVESTIGATIONS.
Año: 2012 vol. 16 p. 651 - 651
No studies had investigated circadian and circannual rhythms of bone biomarkers in whole saliva. We evaluated the salivary daily and seasonal rhythm of carboxy-terminal telopeptide of type I collagen (CTX) and bone alkaline phosphatase (b-ALP). Forty clinical and oral healthy ambulatory pre- and postmenopausal women from two southern Argentine cities: Comodoro Rivadavia (latitude 45º S) and Ushuaia (latitude 54º S) were included in the study. CTX levels were evaluated in serum, urine, and saliva, and b-ALP levels were measured in serum and saliva. In both groups of women, salivary CTX showed a maximum percentage of change early in the morning (80%) and a minimum in the late afternoon (45%), similarly to the pattern observed in urinary samples. No daily rhythm was observed in serum or salivary b-ALP. 25-Hydroxyvitamin D levels decreased in winter vs. summer (p