Field trial of a BLV attenuated vaccine under productive conditions

PETERSEN, MARCOS IVÁN; SUAREZ ARCHILLA, GUILLERMO; ABDALA, ALEJANDRO; CALVINHO LUIS; JACQUES JR; RUIZ, VANESA; TRONO KARIA; WILLEMS, LUC; FRANCO LAUTARO; ALVAREZ IRENE; SAFARI, R

Lima

Congreso; HTLV 2019 meeting; 2019

Sociedad internacional de retrovirologia

Bovine leukemia virus (BLV) is highly endemic in intensive dairy productive areaswhere fatal lymphosarcoma kills around 10% of infected cattle each year. Notreatment or vaccine is still available. Using reverse genetics, we have developed a BLV attenuated strain that replicates at reduced rates and that induces a strongimmune response able to protect against wild type virus challenge. Three previoustrials showed that the strategy is effective under experimental conditions. Right now the efficacy of the attenuated strain to protect against natural challenge is study under real farm conditions in a dairy facility