Solid-Phase Peptide Synthesis Using ChemMatrix®, a Polyethylenglycol (PEG)-based Solid

ALBERICIO FERNANDO; BAYO NURIA; CAMPERI SILVIA A.; CASCONE OSVALDO; CÔTÉ SIMON; CRUZ LUIS J.; ERRACHID ABDELHAMID; FURIC ROBERT; GARCIA-MARTÍN FAYNA; GARCIA-RAMOS YESICA; IANNUCCI NANCY B.; MARANI MARIELA M.; PLA-ROCA MATEU; QUINTANAR-AUDELO MARTINA; SAMITIER J.; TULLA-PUCHE JUDIT

Understanding Biology Using Peptides

Springer

Lugar: New York; Año: 2006; p. 114 - 115

Polystyrene (PS) and PEG-PS resins are currently the most widely used supports for SPS. Although large numbers of peptides and small molecules can be prepared using these supports, there is an ever-increasing need for resins that are suited to more universal applications. In this regard, amphiphilic matrices containing only PEG are very attractive. ChemMatrix, a novel 100% PEG-based resin, is herein introduced. ChemMatrix exhibits good loading and is a user friendly resin. It shows excellent performance for the preparation of hydrophobic peptides as well as for one-bead-one-peptide libraries. Nanotechnologic techniques like FIB (Focused Ion Beam) will be used for the bead-by-bead characterization of ChemMatrix.