Long noncoding RNAs in root developmental plasticity

MOREAU J; LELANDAIS C; CRESPI M; ARIEL FD

Paris

Conferencia; International Conference on Arabidopsis Research; 2015

ICAR

In recent years, noncoding RNAs have emerged as major components of the eukaryotic transcriptome. The production of 24nt siRNAs depends on noncoding transcription mediated by the plant-specific RNA polymerases Pol IV and Pol V,leading to DNA methylation and transcriptional gene silencing. Besides, Pol II is also capable of transcribing functional long noncoding RNAs (lncRNAs). Genome wide analyses have revealed the existence of thousands of lncRNAs in several plant species. In the last years, several Pol II lncRNAs have been characterized in a wide range of regulatory mechanisms in plants, including the recruitment of chromatin remodelers, the modulation of alternative splicing factors, the fine-tune of miRNA activity or the control of mRNA translation or accumulation. Recently, dual noncoding transcription by alternative polymerase complexes was implicated in epigenetic and chromatin conformation dynamics, impacting gene expression. In our lab, we study the role of lncRNAs in the controlof gene expression, leading to the modulation of far-reaching developmental outputs.