Multifunctional conjugated polymer nanoparticles for Photodynamic Therapy against Glioblastoma: Synthesis, characterization and preclinical trials

IBARRA L.E.

Madrid

Seminario; Seminario del Departamento de Fisiopatología Endocrina y del Sistema Nervioso; 2019

Departamento de Fisiopatología Endocrina y del Sistema Nervioso. Instituto de Investigaciones Biomédicas CSIC-UAM

The possibility of bringing together several functions into a single nanostructure offers great potential in theranostic nanomedicine. Fluorescence and magnetic resonance dual-modal imaging nanoprobes are highly desired materials in molecular imaging, but also have potential use in clinical diagnosis with high precision and accuracy. Conjugated polymer nanoparticles (CPNs) possess many useful properties including high brightness, excellent photostability, good water-dispersibility, low cytotoxicity, and easy synthesis and functionalization, showing promising application in bioimaging and photo-assisted anticancer therapy1?3. Through the incorporation of an appropriate metal core into CPNs, its application as a T1/T2-enhanced magnetic resonance contrast agent could be possible. Preclinical trials regarding biosafety, pharmacokinetics are studied in this work employing Glioblastoma in vivo model. Our results, incorporating fluorophore and metal complex or other functional unit into one CPNs, provide a potential design strategy to fabricate dual/multi-modality theranostic agents for in vitro and in vivo applications in future.