Metallated doped conjugated polymer nanoparticles as bimodal imaging agent for cancer detection: application in a preclinical glioblastoma model

GUILLEN GOMEZ M.; RIVAROLA V.A.; IBARRA L.E.; MORALES G; ARIAS RAMOS N.; CHESTA C.A.; LOPEZ LARRUBIA P; PALACIOS R.E.

Rotterdam

Congreso; ESMRMB 2019, 36th Annual Scientific Meeting; 2019

European Society for Magnetic Resonance in Medicine and Biology

The possibility of bringing together several functions into a single nanostructure offers great potential in theranostic nanomedicine. Fluorescence and magnetic resonance dual-modal imaging nanoprobes are highly desired materials in molecular imaging, but also have potential use in clinical diagnosis with high precision and accuracy. Conjugated polymer nanoparticles (CPNs) possess many useful properties including high brightness, excellent photostability, good water-dispersibility, low cytotoxicity, and easy synthesis and functionalization, showing promising application in bioimaging and photo-assisted anticancer therapy1?3. Through the incorporation of an appropriate metal core into CPNs, its application as a T1/T2-enhanced magnetic resonance contrast agent could be possible.