Metallated doped conjugated polymer nanoparticles as bimodal imaging agent for cancer detection: Application in a preclinical glioblastoma modeL in: ESMRMB 2019, 36th Annual Scientific Meeting, Rotterdam, NL, October 3–October 5: Abstracts, Friday

IBARRA L.E.; MORALES G; LOPEZ-LARRUBIA P.; GUILLEN GOMEZ M.; RIVAROLA V.A.; ARIAS-RAMOS N.; CHESTA C.A.; PALACIOS R.E.

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

SPRINGER

Año: 2019 vol. 32 p. 107 - 233

0968-5243

The possibility of bringing together severalfunctions into a single nanostructure offers great potential in theranosticnanomedicine. Fluorescence and magnetic resonance dualmodalimaging nanoprobes are highly desired materials in molecularimaging, but also have potential use in clinical diagnosis with highprecision and accuracy. Conjugated polymer nanoparticles (CPNs)possess many useful properties including high brightness, excellentphotostability, good water-dispersibility, low cytotoxicity, and easysynthesis and functionalization, showing promising application inbioimaging and photo-assisted anticancer therapy1-3. Through theincorporation of an appropriate metal core into CPNs, its applicationas a T1/T2-enhanced magnetic resonance contrast agent could bepossible.