Piroxicam‐Loaded Nanostructured Lipid Nanocarriers Modified with Salicylic Acid: The Effect on Drug Release

COBO SOLÍS, AIRAM K.; OTAROLA, JESSICA J.; MOLINA, PATRICIA G.; OTAROLA, JESSICA J.; MOLINA, PATRICIA G.; MARIANO CORREA, N.; MARIANO CORREA, N.; COBO SOLÍS, AIRAM K.

ChemistrySelect

Wiley-VCH

Lugar: Weinheim; Año: 2020 vol. 5 p. 804 - 809

2365-6549

Piroxicam-loaded nanostructured lipid carriers modified withsalicylic acid (SA) were developed. The modified systemshowed similar properties to the previously studied lipidcarriers without the acid incorporation but it presents moredynamic characteristics. SA favored the interaction betweennanoparticles which was reflected in a size increase in a shortertime. As well, there was a close relationship between the sizeincrease and the drug release performance. Square wavevoltammetry was selected as an alternative technique to studythe drug release. In vitro studies showed that the nanocarriersystem modification caused a piroxicam (PX) fast release,reducing the analysis times. Also, it was observed an increaseon the drug release percentage, obtaining values of up to 93%.Thus, the modified system is able to control and improve thePX release. These results bring out the carrier system versatility,modifying the lipid matrix it is possible to modulate the drugrelease parameters.