Noscapine‐Loaded Nanostructured Lipid Carriers as a Potential Topical Delivery to Bovine Mastitis Treatment

MARIANO CORREA, NÉSTOR; OTAROLA, JESSICA J.; MOLINA, PATRICIA G.; ALEJANDRA LUNA, MARIA

ChemistrySelect

Wiley-VCH

Año: 2020 vol. 5 p. 5922 - 5927

2365-6549

Noscapine (NO) is a lipophilic benzylisoquinoline alkaloid withantioxidant, antitussive and anti-cancer properties. This studyaimed to incorporate this alkaloid into an innovative topicalgel-based on nanostructured lipid carrier (NLCs) to facilitate itsincorporation and distribution into the organism to bovinemastitis treatment.Drug release studies were carried out using square wavevoltammetry (SWV) as an alternative technique. The NLCsshowed a 100% encapsulation efficiency and, a fast releaseprofile, releasing 86.7% of the incorporated NO in 5 hours.On the other hand, the lipid nanoparticles? stability wasanalyzed using SWV and transmission electron microscopetechniques. For these studies, NLCs with and without NOincorporated were immobilized onto a carbon paste electrodeand exposed to free radicals attack. The stability studies wereassisted with dynamic light scattering.The results reveal a promising alternative drug delivery systemfor NO topical application.1. IntroductionBovine mastitis is one of the most expensive pathologies thataffect the dairy industry. This disease is defined as mammarygland inflammation, usually caused by a bacterial infection.[1]The primary tool for mastitis treatment is antimicrobial therapyhowever, the inappropriate use led to the emergence ofantibiotic-resistant strains of bacteria.[2,3] Therefore, alternativeapproaches for bovine mastitis treatment has been attractingthe attention of many researchers. One interesting option isthe exploration of medicinal plants as a substitute forantibiotics.[4]Besides, as an inflammatory response to mastitis, immunecells such