CONICET | Buscador de Institutos y Recursos Humanos

Functionalized fullerenes have shown interesting biomedical applications as potential phototherapeutic agents. The hydrophobic carbon sphere of fullerene C60 can be substituted by cationic groups to obtain amphiphilic structures. These compounds absorb mainly UV light, but absorption in the visible region can be enhanced by anchoring light-harvesting antennas to the C60 core. Upon photoexcitation, fullerenes act as spin converters byeffective intersystem crossing. From this excited state, they can react with ground state molecular oxygen and other substrates to form reactive oxygen species. This process leads to the formation of singlet molecular oxygen by energy transfer or superoxide anion radical by electron transfer. Photodynamic inactivation experiments indicate that cationic fullerenes are highly effective photosensitizers with applications as broad-spectrum antimicrobialagents. In these structures, the hydrophobic character of C60 improves membrane penetration, while the presence of positive charges increases the binding of the fullerene derivatives with microbial cells. Herein, we summarize the progress of antimicrobial photodynamic inactivation based on substituted fullerenes specially designed to improve the photodynamic activity.