INVESTIGADORES
ARRUVITO Maria Lourdes
congresos y reuniones científicas
Título:
CD32 expression promotes T cell activation in severely RSV-infected children
Autor/es:
SANANEZ I; RAIDEN S; HOLGADO P; ERRA DIAZ F; GONZALEZ, F; DAVENPORT C; CAIROLI H; GEFFNER JORGE; ARRUVITO L
Lugar:
Mar del PLata
Reunión:
Congreso; SAIC-SAI-SAFIS 2018; 2018
Institución organizadora:
SAIC-SAI-SAFIS
Resumen:
Background: Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis in young children worldwide. CD32 is a low-affinity Fc receptor with specificity for IgG antibodies commonly expressed on most myeloid cells. Preliminary studies of our group have shown an activating role for CD32 in CD4+ T cells from healthy adults. Here we aim to investigate the expression and function of CD32 in CD4+ T cells from RSV-severely infected children. Specific aims: 1- To analyze the expression of CD32 on CD4+ T cells from RSV-infected. 2- To examine whether CD4+ T cells bind aggregated IgG. 3 - To determine whether the expression of CD32 is associated with phenotypic markers. 4- To explore the biologic response of CD4+ T cells upon ligation with anti-CD32 antibody. Results: We observed an increased frequency of CD32+CD4+T cells in RSV-infected (16%±1.2; n=44) compared with healthy infants (5% ± 0.5; n=8), p