INVESTIGADORES
ARRUVITO Maria Lourdes
congresos y reuniones científicas
Título:
Permissiveness of CD4+ T cells to Respiratory Syncytial Virus infection
Autor/es:
RAIDEN, SILVINA; SANANEZ, INÉS; REMES-LENICOV, FEDERICO; PANDOLFI, JULIETA; CEBALLOS, ANA; GEFFNER, JORGE; ARRUVITO, LOURDES
Reunión:
Simposio; 10th RSV International Symposium; 2016
Resumen:
Background: Although human airway epithelial cells are the main target of RSV, it also infects macrophages, and B cells. We have recently reported that severe RSV infection induces a dramatic reduction in the frequency of peripheral blood FOXP3+CD4+ regulatory T cells in young children. Here, we analyzed the permissiveness of human CD4+ T cells to RSV infection.Aims: 1) to analyze the susceptibility of cord blood CD4+ T cells to RSV infection; 2) to determine whether RSV infection modulates CD4+ T cell function; 3) to determine the expression of RSV in peripheral blood CD4+T cells of infected infants and the correlation between RSV expression and clinical score. Results: Isolated cord blood CD4+T cells were effectively infected by RSV (Moi = 0.5), as revealed by flow cytometry and qRT-PCR. RSV infection significantly (p