INVESTIGADORES
ARRUVITO Maria Lourdes
congresos y reuniones científicas
Título:
CD32 ligation decreased the threshold for CD4+ T cell activation
Autor/es:
HOLGADO, MARÍA PÍA; SANANEZ, INÉS; RAIDEN SILVINA; GEFFNER JORGE; ARRUVITO LOURDES
Lugar:
Mar del PLata
Reunión:
Congreso; SAIC-SAI-SAFIS 2018; 2018
Institución organizadora:
SAIC-SAI-SAFIS
Resumen:
Low affinity receptors for the Fc portion of IgG (FcγRs) represent a critical link between innate and adaptive immunity. The expression and function of FcγRs in myeloid cells, NK and B-cells have been well characterized. However, whether T-cells express FcγRs and if so, what function might exert, is still unknown.We demonstrated that 2.4%±0.4 of resting CD4+ T-cells express CD32 (FcγRII) on the surface (n=18) and 8.5%±1.9 was present also in the intracellular compartment (n=9), revealing the existence of a cytoplasmic pool. Activation of CD4+ T-cells induced a higher expression of CD32 either in the cell surface (0.87%±0.2 vs 10.6%±1.8 unstimulated vs activated cells, respectively; p
