INVESTIGADORES
ARRUVITO Maria Lourdes
congresos y reuniones científicas
Título:
IDENTIFICATION AND CLINICAL RELEVANCE OF NATURALLY OCCURRING HUMAN CD8+HLA-DR+ REGULATORY T CELLS.
Autor/es:
ARRUVITO L; PAYASLIÁN F; BAZ P; POHDORZER A; MACHICOTE A; BILLORDO A; PANDOLFI J; SEMENIUK G; ARRIBALZAGA E; FAINBOIM L
Reunión:
Congreso; SAI/SAIC 2014; 2014
Resumen:
The lack of responsiveness to self and non-self antigens is normally maintained by multiple mechanisms, including the suppressive activities of several T cell subsets. Here, we show that CD8+ T cells from both adult peripheral blood and umbilical cord blood mononuclear cells constitutively expressing HLA-DR represent a natural human CD8+ regulatory T cell subset (Tregs). Their suppressive effect appears to be cell-to-cell contact-dependent and may involve CTLA-4 signaling between neighboring T cells. These Tregs can be expanded in vitro and exhibit a suppressive capacity similar to that observed in ex vivo CD8+HLA-DR+ T cells. The high frequency of CD8+HLA-DR+ T cells we detected in patients with non-small-cell-lung cancer deserve further work to confirm their putative suppressor effect within the tumor.