KIR receptors and HLA-C in the maintenance of pregnancy

A. C. FLORES; C. Y. MARCOS; N. PALADINO; L. ARRUVITO; F. WILLIAMS; D. MIDDLETON; L. FAINBOIM

TISSUE ANTIGENS

Año: 2007 vol. 69 p. 112 - 113

0001-2815

The present study demonstrated that patients who have recurrent spontaneous  abortions (RSA) presented a decreased number of killer immunoglobulin-like  inhibitory receptors (KIR), in particular KIR2DL2. The KIR AA genotype was  found increased in comparison with controls. Individuals AA will also be  homozygous for 2DL3, which in contrast to 2DL2, show a weaker interaction  with C1 ligands and therefore a weaker inhibition. The present study might support  that in RSA patients, the balance between inhibitory and activating receptors  present in natural killer cells is inclined toward an activating state that may  contribute to pregnancy loss